Globoidnan A

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Globoidnan A
IUPAC name 3-(3,4-dihydroxyphenyl)-2-{[4-(3,4-dihydroxyphenyl)-6,7-
dihydroxy-2-naphthyl]-oxomethoxy}propanoic acid
Identifiers
CAS number
PubChem 3013628
SMILES C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C2=CC(=C3C=C(C(=CC3=C2)O)O)C4=CC(=C(C=C4)O)O)O)O
Properties
Molecular formula C26H20O10
Molar mass 492.43 g mol-1
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Globoidnan A is a lignan found in Eucalyptus globoidea, a tree native to Australia, that has been found to inhibit the action of HIV integrase,[1] an enzyme which is responsible for the introduction of HIV viral RNA into a host's cellular DNA. So far it is not known that globoidnan A inhibits the action of other retroviral integrases, although it is likely that this possibility is being investigated.

[edit] References

  1. ^ Ovenden SP, Yu J, Wan SS, et al. (2004). "Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase". Phytochemistry 65 (24): 3255–9. doi:10.1016/j.phytochem.2004.10.006. PMID 15561191. 
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Antivirals used against HIV (HAART) (primarily J05)
Nucleoside & Nucleotide
Reverse Transcriptase
Inhibitors (NRTI)
Non-Nucleoside
Reverse Transcriptase
Inhibitors (NNRTI)
Protease Inhibitors (PI)
Entry/fusion inhibitors
Integrase inhibitors
Maturation inhibitors
Bevirimat† • Vivecon™†
Combined formulations
Other &
experimental agents
°DHHS preferred first-line agent. †Undergoing clinical trials, not FDA approved. ‡Formerly or rarely used agent. §Development terminated.