GLCE

From Wikipedia, the free encyclopedia

Glucuronic acid epimerase

Identifiers

GLCE; HSEPI; KIAA0836

External IDs

Gene ontology
Molecular Function:	• isomerase activity • UDP-glucuronate 5'-epimerase activity
Cellular Component:	• Golgi apparatus • membrane • integral to membrane
Biological Process:	• regulation of cell shape • peptidoglycan biosynthetic process • heparan sulfate proteoglycan biosynthetic process • heparin biosynthetic process

Orthologs

Human

Mouse

Refseq

NM_015554 (mRNA)
NP_056369 (protein)

NM_033320 (mRNA)
NP_201577 (protein)

Location

Chr 15: 67.24 - 67.35 Mb

Chr 9: 61.86 - 61.92 Mb

Pubmed search

[1]

[2]

Glucuronic acid epimerase, also known as GLCE, is a human gene.^[1]

[edit] References

^ Entrez Gene: GLCE glucuronic acid epimerase.

[edit] Further reading

Grigorieva E, Eshchenko T, Rykova VI, et al. (2008). "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer.". Int. J. Cancer 122 (5): 1172-6. doi:10.1002/ijc.23203. PMID 17985344.
Ghiselli G, Agrawal A (2006). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway.". Biochem. J. 390 (Pt 2): 493-9. doi:10.1042/BJ20050152. PMID 15853773.
Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U (2004). "Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate.". J. Biol. Chem. 279 (15): 14631-8. doi:10.1074/jbc.M313760200. PMID 14718527.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Crawford BE, Olson SK, Esko JD, Pinhal MA (2001). "Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase.". J. Biol. Chem. 276 (24): 21538-43. doi:10.1074/jbc.M100880200. PMID 11279150.
Li JP, Gong F, El Darwish K, et al. (2001). "Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate.". J. Biol. Chem. 276 (23): 20069-77. doi:10.1074/jbc.M011783200. PMID 11274177.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355-64. PMID 10048485.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549.