GKN1

From Wikipedia, the free encyclopedia

Gastrokine 1

Identifiers

GKN1; CA11; AMP18; BRICD1; FOV; MGC70354; foveolin

External IDs

OMIM: 606402 MGI: 1913533 HomoloGene: 10487

Gene ontology
Molecular Function:	• molecular_function • growth factor activity
Cellular Component:	• cellular_component • secretory granule
Biological Process:	• regulation of progression through cell cycle • digestion • cell proliferation • positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019617 (mRNA)
NP_062563 (protein)

NM_025466 (mRNA)
NP_079742 (protein)

Location

Chr 2: 69.06 - 69.06 Mb

Chr 6: 87.31 - 87.32 Mb

Pubmed search

[1]

[2]

Gastrokine 1, also known as GKN1, is a human gene.^[1]

The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.^[1]

[edit] References

^ ^a ^b Entrez Gene: GKN1 gastrokine 1.

[edit] Further reading

Yoshikawa Y, Mukai H, Hino F, et al. (2000). "Isolation of two novel genes, down-regulated in gastric cancer.". Jpn. J. Cancer Res. 91 (5): 459–63. PMID 10835488.
Shiozaki K, Nakamori S, Tsujie M, et al. (2001). "Human stomach-specific gene, CA11, is down-regulated in gastric cancer.". Int. J. Oncol. 19 (4): 701–7. PMID 11562744.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Martin TE, Powell CT, Wang Z, et al. (2003). "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa.". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2): G332–43. doi:10.1152/ajpgi.00453.2002. PMID 12851218.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Westley BR, Griffin SM, May FE (2005). "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C.". Biochemistry 44 (22): 7967–75. doi:10.1021/bi047287n. PMID 15924415.
Walsh-Reitz MM, Huang EF, Musch MW, et al. (2005). "AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (1): G163–71. doi:10.1152/ajpgi.00013.2005. PMID 15961882.
Nardone G, Rippa E, Martin G, et al. (2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection.". Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 39 (2): 122–9. doi:10.1016/j.dld.2006.09.017. PMID 17092786.