GIPC1

From Wikipedia, the free encyclopedia

GIPC PDZ domain containing family, member 1

Identifiers

GIPC1; C19orf3; GIPC; GLUT1CBP; Hs.6454; IIP-1; MGC15889; MGC3774; NIP; RGS19IP1; SEMCAP; SYNECTIIN; TIP-2

External IDs

OMIM: 605072 MGI: 1926252 HomoloGene: 21167

Gene ontology
Molecular Function:	• actin binding • receptor binding • protein binding • protein homodimerization activity
Cellular Component:	• membrane fraction • soluble fraction • cytoplasm • cytosol • cell cortex • synaptic vesicle • vesicle membrane • membrane • cytoplasmic membrane-bound vesicle • dendritic spine • dendritic shaft
Biological Process:	• G-protein coupled receptor protein signaling pathway • synaptic transmission • glutamate secretion • regulation of synaptic plasticity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005716 (mRNA)
NP_005707 (protein)

NM_018771 (mRNA)
NP_061241 (protein)

Location

Chr 19: 14.45 - 14.47 Mb

Chr 8: 86.54 - 86.55 Mb

Pubmed search

[1]

[2]

GIPC PDZ domain containing family, member 1, also known as GIPC1, is a human gene.^[1]

[edit] References

^ Entrez Gene: GIPC1 GIPC PDZ domain containing family, member 1.

[edit] Further reading

Katoh M (2002). "GIPC gene family (Review).". Int. J. Mol. Med. 9 (6): 585–9. PMID 12011974.
Hasson T (2004). "Myosin VI: two distinct roles in endocytosis.". J. Cell. Sci. 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819–30. PMID 8895530.
De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. PMID 8986788.
Rousset R, Fabre S, Desbois C, et al. (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.". Oncogene 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.
De Vries L, Lou X, Zhao G, et al. (1998). "GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP.". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12340–5. PMID 9770488.
Bunn RC, Jensen MA, Reed BC (1999). "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton.". Mol. Biol. Cell 10 (4): 819–32. PMID 10198040.
Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF.". J. Biol. Chem. 274 (20): 14137–46. PMID 10318831.
Cai H, Reed RR (1999). "Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1.". J. Neurosci. 19 (15): 6519–27. PMID 10414980.
Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
Gao Y, Li M, Chen W, Simons M (2000). "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration.". J. Cell. Physiol. 184 (3): 373–9. doi:10.1002/1097-4652(200009)184:3<373::AID-JCP12>3.0.CO;2-I. PMID 10911369.
Von Kap-Herr C, Kandala G, Mann SS, et al. (2000). "Assignment of PDZ domain-containing protein GIPC gene (C19orf3) to human chromosome band 19p13.1 by in situ hybridization and radiation hybrid mapping.". Cytogenet. Cell Genet. 89 (3-4): 234–5. PMID 10965131.
Lou X, Yano H, Lee F, et al. (2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways.". Mol. Biol. Cell 12 (3): 615–27. PMID 11251075.
Liu TF, Kandala G, Setaluri V (2001). "PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1).". J. Biol. Chem. 276 (38): 35768–77. doi:10.1074/jbc.M103585200. PMID 11441007.
Ligensa T, Krauss S, Demuth D, et al. (2001). "A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor.". J. Biol. Chem. 276 (36): 33419–27. doi:10.1074/jbc.M104509200. PMID 11445579.
Tani TT, Mercurio AM (2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B.". J. Biol. Chem. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.
Blobe GC, Liu X, Fang SJ, et al. (2001). "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC.". J. Biol. Chem. 276 (43): 39608–17. doi:10.1074/jbc.M106831200. PMID 11546783.
Awan A, Lucic MR, Shaw DM, et al. (2002). "5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis.". Biochem. Biophys. Res. Commun. 290 (3): 1030–6. doi:10.1006/bbrc.2001.6288. PMID 11798178.
El Mourabit H, Poinat P, Koster J, et al. (2002). "The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.". Matrix Biol. 21 (2): 207–14. PMID 11852236.
Lou X, McQuistan T, Orlando RA, Farquhar MG (2002). "GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function.". J. Am. Soc. Nephrol. 13 (4): 918–27. PMID 11912251.