GIMAP5

From Wikipedia, the free encyclopedia

GTPase, IMAP family member 5

Identifiers

GIMAP5; FLJ11296; HIMAP3; IAN4; IAN4L1; IAN5; IMAP3; hIAN5

External IDs

OMIM: 608086 MGI: 2442232 HomoloGene: 41257

Gene ontology
Molecular Function:	• nucleotide binding • GTP binding
Cellular Component:	• mitochondrion • membrane • integral to membrane • outer membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018384 (mRNA)
NP_060854 (protein)

XM_974104 (mRNA)
XP_979198 (protein)

Location

Chr 7: 150.07 - 150.07 Mb

Chr 6: 48.68 - 48.68 Mb

Pubmed search

[1]

[2]

GTPase, IMAP family member 5, also known as GIMAP5, is a human gene.^[1]

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1.^[1]

[edit] References

^ ^a ^b Entrez Gene: GIMAP5 GTPase, IMAP family member 5.

[edit] Further reading

Dahéron L, Zenz T, Siracusa LD, et al. (2001). "Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity.". Nucleic Acids Res. 29 (6): 1308–16. PMID 11238997.
Stamm O, Krücken J, Schmitt-Wrede HP, et al. (2002). "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.". Gene 282 (1-2): 159–67. PMID 11814688.
Cambot M, Aresta S, Kahn-Perlès B, et al. (2002). "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells.". Blood 99 (9): 3293–301. PMID 11964296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Sandal T, Aumo L, Hedin L, et al. (2004). "Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis.". Mol. Biol. Cell 14 (8): 3292–304. doi:10.1091/mbc.E02-10-0700. PMID 12925764.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zenz T, Roessner A, Thomas A, et al. (2004). "hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies.". Genes Immun. 5 (2): 109–16. doi:10.1038/sj.gene.6364044. PMID 14724691.
Krücken J, Schroetel RM, Müller IU, et al. (2005). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family.". Gene 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID 15474311.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hellquist A, Zucchelli M, Kivinen K, et al. (2007). "The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus.". J. Med. Genet. 44 (5): 314–21. doi:10.1136/jmg.2006.046185. PMID 17220214.
Dalberg U, Markholst H, Hornum L (2007). "Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells.". Int. Immunol. 19 (4): 447–53. doi:10.1093/intimm/dxm009. PMID 17369194.
Shin JH, Janer M, McNeney B, et al. (2007). "IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5.". Genes Immun. 8 (6): 503–12. doi:10.1038/sj.gene.6364413. PMID 17641683.