Gi alpha subunit
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| Identifiers | |
| Symbol | GNAI1 |
| Entrez | 2770 |
| HUGO | 4384 |
| OMIM | 139310 |
| RefSeq | NM_002069 |
| UniProt | P63096 |
| Other data | |
| Locus | Chr. 7 q21-q22 |
| Identifiers | |
| Symbol | GNAI2 |
| Alt. Symbols | GNAI2B |
| Entrez | 2771 |
| HUGO | 4385 |
| OMIM | 139360 |
| RefSeq | NM_002070 |
| UniProt | P04899 |
| Other data | |
| Locus | Chr. 3 p21 |
| Identifiers | |
| Symbol | GNAI3 |
| Entrez | 2773 |
| HUGO | 4387 |
| OMIM | 139370 |
| RefSeq | NM_006496 |
| UniProt | P08754 |
| Other data | |
| Locus | Chr. 1 p13 |
Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit which inhibits the production of cAMP from ATP.
Contents |
[edit] Receptors
The following G-protein coupled receptors couple to the Gi subunit:
- 5-HT receptor type 1
- Adenosine receptor A1 and A3
- Prostaglandins
- D2-like Dopamine Receptors
[edit] Function
Further reading: function of cAMP-dependent protein kinase
Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found at function of cAMP-dependent protein kinase.
[edit] Types
There are several types of Gi: Gia1, Gia2, Gia3 and Gia4
[edit] Gia1
Gia1 or Gi1 is encoded by the gene GNAI1.
[edit] Gia2
Gia2 or Gi2 is encoded by the gene GNAI2.
[edit] Gia3
Gia3 or Gi3 is encoded by the gene GNAI3.
[edit] See also
[edit] External links
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