GHB receptor

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Gamma-hydroxybutyrate receptor or GHB receptor is a receptor that binds gamma-Hydroxybutyric acid. Its existence was predicted by observing the action of its agonists that previously were thought to act on GABA-B receptors.[1] The rat GHB receptor was first cloned and characterised in 2003[2] followed by the human receptor in 2007.[3] It is a G-protein coupled receptor.

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[edit] References

  1. ^ Snead OC (November 2000). "Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor". J. Neurochem. 75 (5): 1986–96. PMID 11032888. 
  2. ^ Andriamampandry C, Taleb O, Viry S, et al (September 2003). "Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB)". FASEB J. 17 (12): 1691–3. doi:10.1096/fj.02-0846fje. PMID 12958178. 
  3. ^ Andriamampandry C, Taleb O, Kemmel V, Humbert JP, Aunis D, Maitre M (March 2007). "Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain". FASEB J. 21 (3): 885–95. doi:10.1096/fj.06-6509com. PMID 17197387. 
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