GGPS1

From Wikipedia, the free encyclopedia

Geranylgeranyl diphosphate synthase 1

PDB rendering based on 2fvi.

Available structures: 2fvi

Identifiers

Symbol(s)

GGPS1; GGPPS; GGPPS1

External IDs

OMIM: 606982 MGI: 1341724 HomoloGene: 31267

Gene ontology
Molecular Function:	• dimethylallyltranstransferase activity • farnesyltranstransferase activity • geranyltranstransferase activity • transferase activity
Cellular Component:	• soluble fraction
Biological Process:	• isoprenoid biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001037277 (mRNA)
NP_001032354 (protein)

XM_977926 (mRNA)
XP_983020 (protein)

Location

Chr 1: 233.56 - 233.57 Mb

n/a

Pubmed search

[1]

[2]

Geranylgeranyl diphosphate synthase 1, also known as GGPS1, is a human gene.^[1]

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1.

[edit] Further reading

Ericsson J, Runquist M, Thelin A, et al. (1993). "Distribution of prenyltransferases in rat tissues. Evidence for a cytosolic all-trans-geranylgeranyl diphosphate synthase.". J. Biol. Chem. 268 (2): 832–8. PMID 8419360.
Ericsson J, Greene JM, Carter KC, et al. (1998). "Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression.". J. Lipid Res. 39 (9): 1731–9. PMID 9741684.
Kuzuguchi T, Morita Y, Sagami I, et al. (1999). "Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.". J. Biol. Chem. 274 (9): 5888–94. PMID 10026212.
Kainou T, Kawamura K, Tanaka K, et al. (1999). "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.". Biochim. Biophys. Acta 1437 (3): 333–40. PMID 10101267.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Bommel H, Xie G, Rossoll W, et al. (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMID 12446740.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kavanagh KL, Dunford JE, Bunkoczi G, et al. (2006). "The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.". J. Biol. Chem. 281 (31): 22004–12. doi:10.1074/jbc.M602603200. PMID 16698791.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Raz T, Nardi V, Azam M, et al. (2007). "Farnesyl transferase inhibitor resistance probed by target mutagenesis.". Blood 110 (6): 2102–9. doi:10.1182/blood-2006-12-064907. PMID 17536018.