GFRA2 (gene)

From Wikipedia, the free encyclopedia

GDNF family receptor alpha 2

Identifiers

GFRA2; GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2

External IDs

OMIM: 601956 MGI: 1195462 HomoloGene: 1145

Gene ontology
Molecular Function:	• receptor activity • glial cell line-derived neurotrophic factor receptor activity • GPI anchor binding
Cellular Component:	• membrane • extrinsic to membrane
Biological Process:	• transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001124622 (mRNA)
XP_001124622 (protein)

NM_008115 (mRNA)
NP_032141 (protein)

Location

Chr 8: 21.59 - 21.7 Mb

Chr 14: 69.63 - 69.71 Mb

Pubmed search

[1]

[2]

GDNF family receptor alpha 2, also known as GFRA2, is a human gene.^[1]

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.^[1]

[edit] References

^ ^a ^b Entrez Gene: GFRA2 GDNF family receptor alpha 2.

[edit] Further reading

Sanicola M, Hession C, Worley D, et al. (1997). "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6238–43. PMID 9177201.
Baloh RH, Tansey MG, Golden JP, et al. (1997). "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.". Neuron 18 (5): 793–802. PMID 9182803.
Klein RD, Sherman D, Ho WH, et al. (1997). "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor.". Nature 387 (6634): 717–21. doi:10.1038/42722. PMID 9192898.
Suvanto P, Wartiovaara K, Lindahl M, et al. (1997). "Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.". Hum. Mol. Genet. 6 (8): 1267–73. PMID 9259272.
Jing S, Yu Y, Fang M, et al. (1998). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family.". J. Biol. Chem. 272 (52): 33111–7. PMID 9407096.
Tansey MG, Baloh RH, Milbrandt J, Johnson EM (2000). "GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival.". Neuron 25 (3): 611–23. PMID 10774729.
Cik M, Masure S, Lesage AS, et al. (2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions.". J. Biol. Chem. 275 (36): 27505–12. doi:10.1074/jbc.M000306200. PMID 10829012.
Vanhorne JB, Gimm O, Myers SM, et al. (2001). "Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease.". Hum. Genet. 108 (5): 409–15. PMID 11409869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yoong LF, Too HP (2007). "Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2.". J. Neurosci. 27 (21): 5603–14. doi:10.1523/JNEUROSCI.4552-06.2007. PMID 17522305.