GFI1B

From Wikipedia, the free encyclopedia

Growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)

Identifiers

External IDs

OMIM: 604383 MGI: 1276578 HomoloGene: 31223

Gene ontology
Molecular Function:	• nucleic acid binding • specific RNA polymerase II transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• G1-specific transcription in mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004188 (mRNA)
NP_004179 (protein)

NM_008114 (mRNA)
NP_032140 (protein)

Location

Chr 9: 134.81 - 134.86 Mb

Chr 2: 28.43 - 28.44 Mb

Pubmed search

[1]

[2]

Growth factor independent 1B (potential regulator of CDKN1A, translocated in CML), also known as GFI1B, is a human gene.^[1]

[edit] References

^ Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML).

[edit] Further reading

Tong B, Grimes HL, Yang TY, et al. (1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.". Mol. Cell. Biol. 18 (5): 2462–73. PMID 9566867.
Rödel B, Wagner T, Zörnig M, et al. (1999). "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases.". Genomics 54 (3): 580–2. doi:10.1006/geno.1998.5601. PMID 9878267.
Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.". Blood 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Huang DY, Kuo YY, Lai JS, et al. (2004). "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene.". Nucleic Acids Res. 32 (13): 3935–46. doi:10.1093/nar/gkh719. PMID 15280509.
Garçon L, Lacout C, Svinartchouk F, et al. (2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells.". Blood 105 (4): 1448–55. doi:10.1182/blood-2003-11-4068. PMID 15507521.
Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells.". Nucleic Acids Res. 33 (16): 5331–42. doi:10.1093/nar/gki838. PMID 16177182.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.". Blood 109 (10): 4406–14. doi:10.1182/blood-2006-08-043331. PMID 17272506.
Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription.". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06. PMID 17420275.