Geranylgeranylglycerol-phosphate geranylgeranyltransferase
From Wikipedia, the free encyclopedia
In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase (EC 2.5.1.42) is an enzyme that catalyzes the chemical reaction
- geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate
Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and sn-3-O-(geranylgeranyl)glycerol 1-phosphate, whereas its two products are diphosphate and 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Other names in common use include geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, and geranylgeranyltransferase II.
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[edit] Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2F6U and 2F6X.
[edit] References
- IUBMB entry for 2.5.1.42
- BRENDA references for 2.5.1.42 (Recommended.)
- PubMed references for 2.5.1.42
- PubMed Central references for 2.5.1.42
- Google Scholar references for 2.5.1.42
- Zhang D-L, Daniels L and Poulter CD (1990). "Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction". J. Am. Chem. Soc. 112: 1264–1265. doi:.
[edit] External links
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- The CAS registry number for this enzyme class is 124650-68-6.
[edit] Gene Ontology (GO) codes
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