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State Route 12 begins in Avondale Estates, DeKalb County, Georgia at its intersection with S.R. 10 and ends at S.R. 10/U.S. 78 in Thomson, Georgia. State Route 12 overlaps U.S. Route 278 its entire length. It is also concurrent with Interstate 20/S.R. 402 from Exit 75, which is S.R. 124 (Turner Hill Road) in Lithonia until it reaches Exit 90 in Covington in Newton County. State Route 12 largely runs parallel to Interstate 20 from DeKalb County, near Atlanta, to McDuffie County.