Gentisate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a gentisate decarboxylase (EC 4.1.1.62) is an enzyme that catalyzes the chemical reaction

2,5-dihydroxybenzoate hydroquinone + CO₂

Hence, this enzyme has one substrate, 2,5-dihydroxybenzoate, and two products, hydroquinone and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming). Other names in common use include 2,5-dihydroxybenzoate decarboxylase, and gentisate carboxy-lyase. This enzyme participates in tyrosine metabolism.

[edit] References

• IUBMB entry for 4.1.1.62
• BRENDA references for 4.1.1.62 (Recommended.)
• PubMed references for 4.1.1.62
• PubMed Central references for 4.1.1.62
• Google Scholar references for 4.1.1.62
• Grant DJW and Patel JC (1969). "Non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid, and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes)". J. Microbiol. Serol. 35: 325–343. 

[edit] External links

The CAS registry number for this enzyme class is 37290-54-3.

• IUBMB entry for 4.1.1.62

• KEGG entry for 4.1.1.62

• BRENDA entry for 4.1.1.62

• NiceZyme view of 4.1.1.62

• EC2PDB: PDB structures for 4.1.1.62

• PRIAM entry for 4.1.1.62

• PUMA2 entry for 4.1.1.62

• IntEnz: Integrated Enzyme entry for 4.1.1.62

• MetaCyc entry for 4.1.1.62

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047923: gentisate decarboxylase

• AMIGO entry for GO code 0047923: gentisate decarboxylase