Gentisate 1,2-dioxygenase

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In enzymology, a gentisate 1,2-dioxygenase (EC 1.13.11.4) is an enzyme that catalyzes the chemical reaction

2,5-dihydroxybenzoate + O₂ $\rightleftharpoons$ maleylpyruvate

Thus, the two substrates of this enzyme are 2,5-dihydroxybenzoate and O₂, whereas its product is maleylpyruvate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is gentisate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include gentisate oxygenase, 2,5-dihydroxybenzoate dioxygenase, gentisate dioxygenase, and gentisic acid oxidase. This enzyme participates in tyrosine metabolism. It employs one cofactor, iron.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2D40.

[edit] References

IUBMB entry for 1.13.11.4
BRENDA references for 1.13.11.4 (Recommended.)
PubMed references for 1.13.11.4
PubMed Central references for 1.13.11.4
Google Scholar references for 1.13.11.4
Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.
Sugiyama S, Yano K, Komagata K and Arima K (1960). "Metabolites of aromatic compounds by microbes. Part VII. Gentisic acid oxidase". Bull. Agric. Chem. Soc. Jpn 24: 243–248.
Sugiyama S, Yano K and Arima K (1960). "Metabolites of aromatic compounds by microbes. Part VII. Further studies of gentisic acid oxidase". Bull. Agric. Chem. Soc. Jpn 24: 249–254.