Gentamicin 2"-nucleotidyltransferase

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In enzymology, a gentamicin 2"-nucleotidyltransferase (EC 2.7.7.46) is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + gentamicin $\rightleftharpoons$ diphosphate + 2"-nucleotidylgentamicin

Thus, the two substrates of this enzyme are nucleoside triphosphate and gentamicin, whereas its two products are diphosphate and [[2-nucleotidylgentamicin]].

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:gentamicin 2"-nucleotidyltransferase. Other names in common use include gentamicin 2"-adenylyltransferase, aminoglycoside adenylyltransferase, and gentamicin 2"-nucleotidyltransferase.

[edit] References

IUBMB entry for 2.7.7.46
BRENDA references for 2.7.7.46 (Recommended.)
PubMed references for 2.7.7.46
PubMed Central references for 2.7.7.46
Google Scholar references for 2.7.7.46
Angelatou F, Litsas SB, Kontomichalou P (Tokyo). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa". J. Antibiot.: 235–44. PMID 6281224.
Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H (Tokyo). "The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B". J. Antibiot.: 913–4. PMID 4946513.
Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T (Tokyo). "Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor". J. Antibiot.: 911–2. PMID 4946512.