Gem-associated protein 7

From Wikipedia, the free encyclopedia

Gem (nuclear organelle) associated protein 7

PDB rendering based on 1y96.

Available structures: 1y96

Identifiers

Symbol(s)

GEMIN7; SIP3

External IDs

OMIM: 607419 MGI: 1916981 HomoloGene: 11668

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • nucleoplasm • spliceosome • cytoplasm • nuclear body
Biological Process:	• spliceosomal snRNP biogenesis • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001007269 (mRNA)
NP_001007270 (protein)

NM_027189 (mRNA)
NP_081465 (protein)

Location

Chr 19: 50.27 - 50.29 Mb

Chr 7: 18.72 - 18.73 Mb

Pubmed search

[1]

[2]

Gem (nuclear organelle) associated protein 7, also known as GEMIN7, is a human gene.^[1]

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7.

[edit] Further reading

Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2007). "Gemin8 is required for the architecture and function of the survival motor neuron complex.". J. Biol. Chem. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Grimmler M, Otter S, Peter C, et al. (2006). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.". Hum. Mol. Genet. 14 (20): 3099–111. doi:10.1093/hmg/ddi343. PMID 16159890.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex.". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.