Gem-associated protein 6

From Wikipedia, the free encyclopedia

Gem (nuclear organelle) associated protein 6

PDB rendering based on 1y96.

Available structures: 1y96

Identifiers

Symbol(s)

GEMIN6; FLJ23459

External IDs

OMIM: 607006 MGI: 1914492 HomoloGene: 11711

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • nucleoplasm • spliceosome • cytoplasm • nuclear body
Biological Process:	• spliceosome assembly • spliceosomal snRNP biogenesis • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024775 (mRNA)
NP_079051 (protein)

NM_026053 (mRNA)
NP_080329 (protein)

Location

Chr 2: 38.86 - 38.86 Mb

Chr 17: 80.13 - 80.14 Mb

Pubmed search

[1]

[2]

Gem (nuclear organelle) associated protein 6, also known as GEMIN6, is a human gene.^[1]

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6.

[edit] Further reading

Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component.". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex.". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure.". Structure 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2007). "Gemin8 is required for the architecture and function of the survival motor neuron complex.". J. Biol. Chem. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.