GEMIN5

From Wikipedia, the free encyclopedia

Gem (nuclear organelle) associated protein 5

Identifiers

GEMIN5; DKFZP586M1824; MGC142174

External IDs

OMIM: 607005 MGI: 2449311 HomoloGene: 9155

Gene ontology
Molecular Function:	• protein binding • snRNA binding
Cellular Component:	• nucleus • nucleoplasm • spliceosome • cytoplasm • nuclear body
Biological Process:	• spliceosomal snRNP biogenesis • protein complex assembly • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015465 (mRNA)
NP_056280 (protein)

NM_172558 (mRNA)
NP_766146 (protein)

Location

Chr 5: 154.25 - 154.3 Mb

Chr 11: 57.94 - 57.98 Mb

Pubmed search

[1]

[2]

Gem (nuclear organelle) associated protein 5, also known as GEMIN5, is a human gene.^[1]

GEMIN5 is part of a large macromolecular complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5.

[edit] Further reading

Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.". J. Biol. Chem. 277 (7): 5631-6. doi:10.1074/jbc.M109448200. PMID 11714716.
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex.". J. Biol. Chem. 277 (35): 31957-62. doi:10.1074/jbc.M203478200. PMID 12065586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Battle DJ, Lau CK, Wan L, et al. (2006). "The Gemin5 protein of the SMN complex identifies snRNAs.". Mol. Cell 23 (2): 273-9. doi:10.1016/j.molcel.2006.05.036. PMID 16857593.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kim EK, Noh KT, Yoon JH, et al. (2007). "Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5.". Cell Death Differ. 14 (8): 1518-28. doi:10.1038/sj.cdd.4402157. PMID 17541429.
Hao le T, Fuller HR, Lam le T, et al. (2007). "Absence of gemin5 from SMN complexes in nuclear Cajal bodies.". BMC Cell Biol. 8: 28. doi:10.1186/1471-2121-8-28. PMID 17640370.
Battle DJ, Kasim M, Wang J, Dreyfuss G (2007). "SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate.". J. Biol. Chem. 282 (38): 27953-9. doi:10.1074/jbc.M702317200. PMID 17640873.