Geissoschizine dehydrogenase

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In enzymology, a geissoschizine dehydrogenase (EC 1.3.1.36) is an enzyme that catalyzes the chemical reaction

geissoschizine + NADP⁺ 4,21-didehydrogeissoschizine + NADPH

Thus, the two substrates of this enzyme are geissoschizine and NADP⁺, whereas its two products are 4,21-didehydrogeissoschizine and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is geissoschizine:NADP+ 4,21-oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

• IUBMB entry for 1.3.1.36
• BRENDA references for 1.3.1.36 (Recommended.)
• PubMed references for 1.3.1.36
• PubMed Central references for 1.3.1.36
• Google Scholar references for 1.3.1.36
• Pfitzner A and Stockigt J (1982). "Partial-purification and characterization of geissoschizine dehydrogenase from suspension-cultures of Catharanthus roseus". Phytochemistry 21: 1585–1588. 

[edit] External links

The CAS registry number for this enzyme class is 84399-94-0.

• IUBMB entry for 1.3.1.36

• KEGG entry for 1.3.1.36

• BRENDA entry for 1.3.1.36

• NiceZyme view of 1.3.1.36

• EC2PDB: PDB structures for 1.3.1.36

• PRIAM entry for 1.3.1.36

• PUMA2 entry for 1.3.1.36

• IntEnz: Integrated Enzyme entry for 1.3.1.36

• MetaCyc entry for 1.3.1.36

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047920: geissoschizine dehydrogenase

• AMIGO entry for GO code 0047920: geissoschizine dehydrogenase