GDP-mannose 6-dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a GDP-mannose 6-dehydrogenase (EC 1.1.1.132) is an enzyme that catalyzes the chemical reaction
- GDP-D-mannose + 2 NAD+ + H2O
GDP-D-mannuronate + 2 NADH + 2 H+
The 3 substrates of this enzyme are GDP-D-mannose, NAD+, and H2O, whereas its 3 products are GDP-D-mannuronate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-D-mannose:NAD+ 6-oxidoreductase. Other names in common use include guanosine diphosphomannose dehydrogenase, GDP-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase, and guanosine diphospho-D-mannose dehydrogenase. This enzyme participates in fructose and mannose metabolism.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MFZ, 1MUU, and 1MV8.
[edit] References
- IUBMB entry for 1.1.1.132
- BRENDA references for 1.1.1.132 (Recommended.)
- PubMed references for 1.1.1.132
- PubMed Central references for 1.1.1.132
- Google Scholar references for 1.1.1.132
- Preiss J (1964). "Sugar nucleotide reaction in Arthrobacter. II. Biosynthesis of guanosine diphosphomannuronate". J. Biol. Chem. 239: 3127–3132.
[edit] External links
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- The CAS registry number for this enzyme class is 37250-63-8.
[edit] Gene Ontology (GO) codes
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