GDP-L-fucose synthase

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In enzymology, a GDP-L-fucose synthase (EC 1.1.1.271) is an enzyme that catalyzes the chemical reaction

GDP-L-fucose + NADP⁺ $\rightleftharpoons$ GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H⁺

Thus, the two substrates of this enzyme are GDP-L-fucose and NADP⁺, whereas its 3 products are GDP-4-dehydro-6-deoxy-D-mannose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing). This enzyme is also called GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase. This enzyme participates in fructose and mannose metabolism.

[edit] References

IUBMB entry for 1.1.1.271
BRENDA references for 1.1.1.271 (Recommended.)
PubMed references for 1.1.1.271
PubMed Central references for 1.1.1.271
Google Scholar references for 1.1.1.271
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Somers WS, Stahl ML, Sullivan FX (1998). "GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site". Structure. 6: 1601–12. doi:10.1016/S0969-2126(98)00157-9. PMID 9862812.