GDP-6-deoxy-D-talose 4-dehydrogenase

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In enzymology, a GDP-6-deoxy-D-talose 4-dehydrogenase (EC 1.1.1.135) is an enzyme that catalyzes the chemical reaction

GDP-6-deoxy-D-talose + NAD(P)+ GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H⁺

The 3 substrates of this enzyme are GDP-6-deoxy-D-talose, NAD⁺, and NADP⁺, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase. This enzyme is also called guanosine diphospho-6-deoxy-D-talose dehydrogenase. This enzyme participates in fructose and mannose metabolism.

[edit] References

• IUBMB entry for 1.1.1.135
• BRENDA references for 1.1.1.135 (Recommended.)
• PubMed references for 1.1.1.135
• PubMed Central references for 1.1.1.135
• Google Scholar references for 1.1.1.135
• Markovitz A (1964). "Biosynthesis of guanosine diphosphate D-rhamnose and guanosine diphosphate D-talomethylose from guanosine diphosphate alpha-D-mannose". J. Biol. Chem. 239: 2091–2098. 

[edit] External links

The CAS registry number for this enzyme class is 37250-66-1.

• IUBMB entry for 1.1.1.135

• KEGG entry for 1.1.1.135

• BRENDA entry for 1.1.1.135

• NiceZyme view of 1.1.1.135

• EC2PDB: PDB structures for 1.1.1.135

• PRIAM entry for 1.1.1.135

• PUMA2 entry for 1.1.1.135

• IntEnz: Integrated Enzyme entry for 1.1.1.135

• MetaCyc entry for 1.1.1.135

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047916: GDP-6-deoxy-D-talose 4-dehydrogenase

• AMIGO entry for GO code 0047916: GDP-6-deoxy-D-talose 4-dehydrogenase