GDP-4-dehydro-D-rhamnose reductase

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In enzymology, a GDP-4-dehydro-D-rhamnose reductase (EC 1.1.1.187) is an enzyme that catalyzes the chemical reaction

GDP-6-deoxy-D-mannose + NAD(P)+ $\rightleftharpoons$ GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H⁺

The 3 substrates of this enzyme are GDP-6-deoxy-D-mannose, NAD⁺, and NADP⁺, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase. Other names in common use include GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, and guanosine diphosphate-4-keto-D-rhamnose reductase. This enzyme participates in fructose and mannose metabolism.

[edit] References

IUBMB entry for 1.1.1.187
BRENDA references for 1.1.1.187 (Recommended.)
PubMed references for 1.1.1.187
PubMed Central references for 1.1.1.187
Google Scholar references for 1.1.1.187
Barber GA (1968). "The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant". Biochim. Biophys. Acta. 165: 68–75. PMID 4386238.
Winkler NW, Markovitz A (1971). "Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme". J. Biol. Chem. 246: 5868–76. PMID 4398966.