From Wikipedia, the free encyclopedia
Growth differentiation factor 6 (GDF6) is a protein belonging to the transforming growth factor beta superfamily that may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins,[1] and control eye development.[2][3]
[edit] References
- ^ Chang C, Hemmati-Brivanlou A (1999). "Xenopus GDF6, a new antagonist of noggin and a partner of BMPs". Development 126 (15): 3347–57. PMID 10393114.
- ^ Asai-Coakwell M, French C, Berry K, Ye M, Koss R, Somerville M, Mueller R, van Heyningen V, Waskiewicz A, Lehmann O (2007). "GDF6, a novel locus for a spectrum of ocular developmental anomalies". Am J Hum Genet 80 (2): 306–15. doi:10.1086/511280. PMID 17236135.
- ^ Hanel M, Hensey C. "Eye and neural defects associated with loss of GDF6". BMC Dev Biol 6: 43. doi:10.1186/1471-213X-6-43. PMID 17010201.
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Cell signaling: TGF beta signaling pathway |
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| TGF beta superfamily of ligands |
TGF beta family ( TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins ( BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors ( GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other ( Activin A and B/ Inhibin A and B, Anti-müllerian hormone, Nodal)
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| TGF beta receptors |
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| Transducers/SMAD |
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| Ligand Inhibitors |
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| Coreceptors |
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| Other |
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