From Wikipedia, the free encyclopedia
Growth differentiation factor-1 (GDF1) is a protein belonging to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.[1] It is found in the brain, spinal cord and peripheral nerves of embryos[2][3]
[edit] References
- ^ Rankin C, Bunton T, Lawler A, Lee S (2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat Genet 24 (3): 262–5. doi:10.1038/73472. PMID 10700179.
- ^ Lee S (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc Natl Acad Sci U S A 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMID 2034669.
- ^ Rankin C, Bunton T, Lawler A, Lee S (2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat Genet 24 (3): 262–5. doi:10.1038/73472. PMID 10700179.
|
Cell signaling: TGF beta signaling pathway |
|
| TGF beta superfamily of ligands |
TGF beta family ( TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins ( BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors ( GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other ( Activin A and B/ Inhibin A and B, Anti-müllerian hormone, Nodal)
|
|
| TGF beta receptors |
|
|
| Transducers/SMAD |
|
|
| Ligand Inhibitors |
|
|
| Coreceptors |
|
|
| Other |
|
|
