GDF15

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Growth differentiation factor 15
Identifiers
Symbol(s) GDF15; PDF; GDF-15; MIC-1; MIC1; NAG-1; PLAB; PTGFB
External IDs OMIM: 605312 MGI: 1346047 HomoloGene: 3576
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9518 23886
Ensembl ENSG00000130513 ENSMUSG00000038508
Uniprot Q99988 Q3TU76
Refseq NM_004864 (mRNA)
NP_004855 (protein)		 NM_011819 (mRNA)
NP_035949 (protein)
Location Chr 19: 18.36 - 18.36 Mb Chr 8: 73.56 - 73.56 Mb
Pubmed search [1] [2]

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.[1] GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.[2] GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.[1][2][3]

[edit] References

  1. ^ a b Zimmers T, Jin X, Hsiao E, McGrath S, Esquela A, Koniaris L (2005). "Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury". Shock 23 (6): 543–8. PMID 15897808. 
  2. ^ a b Hsiao E, Koniaris L, Zimmers-Koniaris T, Sebald S, Huynh T, Lee S (2000). "Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury". Mol Cell Biol 20 (10): 3742–51. doi:10.1128/MCB.20.10.3742-3751.2000. PMID 10779363. 
  3. ^ Ago T, Sadoshima J (2006). "GDF15, a cardioprotective TGF-beta superfamily protein". Circ Res 98 (3): 294–7. doi:10.1161/01.RES.0000207919.83894.9d. PMID 16484622. 
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Cell signaling: TGF beta signaling pathway
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