GCM2

From Wikipedia, the free encyclopedia

Glial cells missing homolog 2 (Drosophila)

Identifiers

GCM2; GCMB; hGCMb

External IDs

OMIM: 603716 MGI: 1861438 HomoloGene: 3490

Gene ontology
Molecular Function:	• zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • cellular calcium ion homeostasis • multicellular organismal development • organ morphogenesis • cellular phosphate ion homeostasis • parathyroid gland development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004752 (mRNA)
NP_004743 (protein)

NM_008104 (mRNA)
NP_032130 (protein)

Location

Chr 6: 10.98 - 10.99 Mb

Chr 13: 41.11 - 41.12 Mb

Pubmed search

[1]

[2]

Glial cells missing homolog 2 (Drosophila), also known as GCM2, is a human gene.^[1]

The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila).

[edit] Further reading

Kanemura Y, Hiraga S, Arita N, et al. (1999). "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene.". FEBS Lett. 442 (2-3): 151-6. PMID 9928992.
Kammerer M, Pirola B, Giglio S, Giangrande A (1999). "GCMB, a second human homolog of the fly glide/gcm gene.". Cytogenet. Cell Genet. 84 (1-2): 43-7. PMID 10343099.
Correa P, Akerström G, Westin G (2002). "Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism.". Clin. Endocrinol. (Oxf) 57 (4): 501-5. PMID 12354132.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Maret A, Bourdeau I, Ding C, et al. (2004). "Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin.". J. Clin. Endocrinol. Metab. 89 (1): 8-12. PMID 14715818.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kebebew E, Peng M, Wong MG, et al. (2005). "GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism.". Surgery 136 (6): 1261-6. doi:10.1016/j.surg.2004.06.056. PMID 15657585.
Thomée C, Schubert SW, Parma J, et al. (2005). "GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone.". J. Clin. Endocrinol. Metab. 90 (5): 2487-92. doi:10.1210/jc.2004-2450. PMID 15728199.
Baumber L, Tufarelli C, Patel S, et al. (2006). "Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism.". J. Med. Genet. 42 (5): 443-8. doi:10.1136/jmg.2004.026898. PMID 15863676.