GCM1

From Wikipedia, the free encyclopedia

Glial cells missing homolog 1 (Drosophila)

PDB rendering based on 1odh.

Available structures: 1odh

Identifiers

Symbol(s)

GCM1; GCMA; hGCMa

External IDs

OMIM: 603715 MGI: 108045 HomoloGene: 2702

Gene ontology
Molecular Function:	• transcription factor activity • transcription factor binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • transcription factor complex
Biological Process:	• transcription • regulation of transcription, DNA-dependent • multicellular organismal development • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003643 (mRNA)
NP_003634 (protein)

NM_008103 (mRNA)
NP_032129 (protein)

Location

Chr 6: 53.1 - 53.12 Mb

Chr 9: 77.84 - 77.85 Mb

Pubmed search

[1]

[2]

Glial cells missing homolog 1 (Drosophila), also known as GCM1, is a human gene.^[1]

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: GCM1 glial cells missing homolog 1 (Drosophila).

[edit] Further reading

Akiyama Y, Hosoya T, Poole AM, Hotta Y (1997). "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals.". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14912-6. PMID 8962155.
Yamada K, Ogawa H, Honda S, et al. (1999). "A GCM motif protein is involved in placenta-specific expression of human aromatase gene.". J. Biol. Chem. 274 (45): 32279-86. PMID 10542267.
Nait-Oumesmar B, Copperman AB, Lazzarini RA (2000). "Placental expression and chromosomal localization of the human Gcm 1 gene.". J. Histochem. Cytochem. 48 (7): 915-22. PMID 10858268.
Yamada K, Ogawa H, Tamiya G, et al. (2001). "Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene.". Biochem. Biophys. Res. Commun. 278 (1): 134-9. doi:10.1006/bbrc.2000.3775. PMID 11071865.
Yu C, Shen K, Lin M, et al. (2003). "GCMa regulates the syncytin-mediated trophoblastic fusion.". J. Biol. Chem. 277 (51): 50062-8. doi:10.1074/jbc.M209316200. PMID 12397062.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Chen CP, Chen CY, Yang YC, et al. (2005). "Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia.". Placenta 25 (5): 413-21. doi:10.1016/j.placenta.2003.10.014. PMID 15081636.
Baczyk D, Satkunaratnam A, Nait-Oumesmar B, et al. (2004). "Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta.". Placenta 25 (6): 553-9. doi:10.1016/j.placenta.2003.12.004. PMID 15135239.
Schubert SW, Kardash E, Khan MA, et al. (2005). "Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2.". J. Biol. Chem. 279 (48): 50358-65. doi:10.1074/jbc.M404587200. PMID 15385555.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yang CS, Yu C, Chuang HC, et al. (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system.". J. Biol. Chem. 280 (11): 10083-90. doi:10.1074/jbc.M413986200. PMID 15640526.
Knerr I, Schubert SW, Wich C, et al. (2005). "Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions.". FEBS Lett. 579 (18): 3991-8. doi:10.1016/j.febslet.2005.06.029. PMID 16004993.
Chang CW, Chuang HC, Yu C, et al. (2005). "Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.". Mol. Cell. Biol. 25 (19): 8401-14. doi:10.1128/MCB.25.19.8401-8414.2005. PMID 16166624.
Chuang HC, Chang CW, Chang GD, et al. (2006). "Histone deacetylase 3 binds to and regulates the GCMa transcription factor.". Nucleic Acids Res. 34 (5): 1459-69. doi:10.1093/nar/gkl048. PMID 16528103.
Fujito N, Samura O, Miharu N, et al. (2007). "Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia.". Hiroshima J. Med. Sci. 55 (1): 9-15. PMID 16594548.
Chou CC, Chang C, Liu JH, et al. (2007). "Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a.". J. Biol. Chem. 282 (37): 27239-49. doi:10.1074/jbc.M700351200. PMID 17646165.