GCLM

From Wikipedia, the free encyclopedia


Glutamate-cysteine ligase, modifier subunit
Identifiers
Symbol(s) GCLM; GLCLR
External IDs OMIM: 601176 MGI: 104995 HomoloGene: 1557
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2730 14630
Ensembl ENSG00000023909 ENSMUSG00000028124
Uniprot P48507 Q3T9P2
Refseq NM_002061 (mRNA)
NP_002052 (protein)		 NM_008129 (mRNA)
NP_032155 (protein)
Location Chr 1: 94.12 - 94.15 Mb Chr 3: 122.24 - 122.26 Mb
Pubmed search [1] [2]

Glutamate-cysteine ligase, modifier subunit, also known as GCLM, is a human gene.[1]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.[1]

[edit] References

  1. ^ a b Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit.

[edit] Further reading

  • Dickinson DA, Levonen AL, Moellering DR, et al. (2005). "Human glutamate cysteine ligase gene regulation through the electrophile response element.". Free Radic. Biol. Med. 37 (8): 1152-9. doi:10.1016/j.freeradbiomed.2004.06.011. PMID 15451055. 
  • Gipp JJ, Bailey HH, Mulcahy RT (1995). "Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues.". Biochem. Biophys. Res. Commun. 206 (2): 584-9. PMID 7826375. 
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42-50. doi:10.1006/geno.1994.1457. PMID 7829101. 
  • Tsuchiya K, Mulcahy RT, Reid LL, et al. (1997). "Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3.". Genomics 30 (3): 630-2. doi:10.1006/geno.1995.1293. PMID 8825659. 
  • Sierra-Rivera E, Dasouki M, Summar ML, et al. (1997). "Assignment of the human gene (GLCLR) that encodes the regulatory subunit of gamma-glutamylcysteine synthetase to chromosome 1p21.". Cytogenet. Cell Genet. 72 (2-3): 252-4. PMID 8978789. 
  • Misra I, Griffith OW (1998). "Expression and purification of human gamma-glutamylcysteine synthetase.". Protein Expr. Purif. 13 (2): 268-76. doi:10.1006/prep.1998.0897. PMID 9675072. 
  • Rozet JM, Gerber S, Perrault I, et al. (1998). "Structure and refinement of the physical mapping of the gamma- glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma.". Cytogenet. Cell Genet. 82 (1-2): 91-4. PMID 9841137. 
  • Tu Z, Anders MW (1999). "Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.". Biochem. J. 336 ( Pt 3): 675-80. PMID 9841880. 
  • Tipnis SR, Blake DG, Shepherd AG, McLellan LI (1999). "Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance.". Biochem. J. 337 ( Pt 3): 559-66. PMID 9895302. 
  • Galloway DC, Blake DG, McLellan LI (1999). "Regulation of gamma-glutamylcysteine synthetase regulatory subunit (GLCLR) gene expression: identification of the major transcriptional start site in HT29 cells.". Biochim. Biophys. Acta 1446 (1-2): 47-56. PMID 10395918. 
  • Levonen AL, Lapatto R, Saksela M, Raivio KO (2000). "Expression of gamma-glutamylcysteine synthetase during development.". Pediatr. Res. 47 (2): 266-70. PMID 10674357. 
  • Nakamura S, Kugiyama K, Sugiyama S, et al. (2002). "Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.". Circulation 105 (25): 2968-73. PMID 12081989. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nakamura S, Sugiyama S, Fujioka D, et al. (2003). "Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function.". Circulation 108 (12): 1425-7. doi:10.1161/01.CIR.0000091255.63645.98. PMID 12975258. 
  • Inoue Y, Tomisawa M, Yamazaki H, et al. (2004). "The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer.". Int. J. Oncol. 23 (5): 1333-9. PMID 14532974. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Song IS, Tatebe S, Dai W, Kuo MT (2005). "Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling.". J. Biol. Chem. 280 (31): 28230-40. doi:10.1074/jbc.M413103200. PMID 15946948. 
  • Chen Y, Shertzer HG, Schneider SN, et al. (2005). "Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.". J. Biol. Chem. 280 (40): 33766-74. doi:10.1074/jbc.M504604200. PMID 16081425. 
  • Diaz-Hernandez JI, Almeida A, Delgado-Esteban M, et al. (2006). "Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons.". J. Biol. Chem. 280 (47): 38992-9001. doi:10.1074/jbc.M507065200. PMID 16183645. 
 This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.