GCHFR

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GTP cyclohydrolase I feedback regulator
PDB rendering based on 1is7.
Available structures: 1is7, 1is8, 1jg5, 1wpl
Identifiers
Symbol(s) GCHFR; P35; GFRP; HsT16933; MGC138467; MGC138469
External IDs OMIM: 602437 MGI: 2443977 HomoloGene: 3849
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2644 320415
Ensembl ENSG00000137880 ENSMUSG00000046814
Uniprot P30047 Q4VAF4
Refseq NM_005258 (mRNA)
NP_005249 (protein)		 NM_177157 (mRNA)
NP_796131 (protein)
Location Chr 15: 38.84 - 38.85 Mb Chr 2: 118.86 - 118.86 Mb
Pubmed search [1] [2]

GTP cyclohydrolase I feedback regulator, also known as GCHFR, is a human gene.[1]

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.[1]

[edit] References

  1. ^ a b Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator.

[edit] Further reading

  • Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992-1001. PMID 1286669. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Milstien S, Jaffe H, Kowlessur D, Bonner TI (1996). "Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP.". J. Biol. Chem. 271 (33): 19743-51. PMID 8702680. 
  • Yoneyama T, Brewer JM, Hatakeyama K (1997). "GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression.". J. Biol. Chem. 272 (15): 9690-6. PMID 9092499. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Bader G, Schiffmann S, Herrmann A, et al. (2001). "Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP.". J. Mol. Biol. 312 (5): 1051-7. doi:10.1006/jmbi.2001.5011. PMID 11580249. 
  • Werner ER, Bahrami S, Heller R, Werner-Felmayer G (2002). "Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein.". J. Biol. Chem. 277 (12): 10129-33. doi:10.1074/jbc.M107326200. PMID 11799107. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gesierich A, Niroomand F, Tiefenbacher CP (2003). "Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism.". Basic Res. Cardiol. 98 (2): 69-75. doi:10.1007/s00395-003-0394-y. PMID 12607127. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kalivendi S, Hatakeyama K, Whitsett J, et al. (2006). "Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?". Free Radic. Biol. Med. 38 (4): 481-91. doi:10.1016/j.freeradbiomed.2004.11.004. PMID 15649650. 
  • Chavan B, Gillbro JM, Rokos H, Schallreuter KU (2007). "GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes.". J. Invest. Dermatol. 126 (11): 2481-9. doi:10.1038/sj.jid.5700425. PMID 16778797. 
  • Ohta E, Funayama M, Ichinose H, et al. (2006). "Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia.". Arch. Neurol. 63 (11): 1605-10. doi:10.1001/archneur.63.11.1605. PMID 17101830. 
  • Kontostavlaki DP, Panayotacopoulou MT, Sluijs JA, et al. (2007). "Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR.". Neuroendocrinology 84 (6): 386-95. doi:10.1159/000097487. PMID 17135716. 
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