GCA (gene)

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Grancalcin, EF-hand calcium binding protein
PDB rendering based on 1f4o.
Available structures: 1f4o, 1f4q, 1k94, 1k95
Identifiers
Symbol(s) GCA; GCL
External IDs OMIM: 607030 MGI: 1918521 HomoloGene: 22702
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 25801 227960
Ensembl ENSG00000115271 ENSMUSG00000026893
Uniprot P28676 Q8VC88
Refseq NM_012198 (mRNA)
NP_036330 (protein)		 NM_145523 (mRNA)
NP_663498 (protein)
Location Chr 2: 162.91 - 162.93 Mb Chr 2: 62.47 - 62.49 Mb
Pubmed search [1] [2]

Grancalcin, EF-hand calcium binding protein, also known as GCA, is a human gene.[1]

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[1]

[edit] References

  1. ^ a b Entrez Gene: GCA grancalcin, EF-hand calcium binding protein.

[edit] Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hansen C, Tarabykina S, la Cour JM, et al. (2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro.". FEBS Lett. 545 (2-3): 151–4. PMID 12804766. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Jia J, Borregaard N, Lollike K, Cygler M (2002). "Structure of Ca(2+)-loaded human grancalcin.". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 12): 1843–9. PMID 11717497. 
  • Lollike K, Johnsen AH, Durussel I, et al. (2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner.". J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160. 
  • Jia J, Han Q, Borregaard N, et al. (2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.". J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868. 
  • Maki M, Narayana SV, Hitomi K (1998). "A growing family of the Ca2+-binding proteins with five EF-hand motifs.". Biochem. J. 328 ( Pt 2): 718–20. PMID 9441591. 
  • Boyhan A, Casimir CM, French JK, et al. (1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes.". J. Biol. Chem. 267 (5): 2928–33. PMID 1737748. 
  • Teahan CG, Totty NF, Segal AW (1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils.". Biochem. J. 286 ( Pt 2): 549–54. PMID 1530588. 
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