GBX2

From Wikipedia, the free encyclopedia

Gastrulation brain homeobox 2

Identifiers

External IDs

OMIM: 601135 MGI: 95668 HomoloGene: 1138

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• patterning of blood vessels • neural crest cell migration • regulation of transcription, DNA-dependent • axon guidance • antimicrobial humoral response • hindbrain development • tube morphogenesis • inner ear morphogenesis • autonomic nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001485 (mRNA)
NP_001476 (protein)

NM_010262 (mRNA)
NP_034392 (protein)

Location

Chr 2: 236.74 - 236.74 Mb

Chr 1: 91.76 - 91.76 Mb

Pubmed search

[1]

[2]

Gastrulation brain homeobox 2, also known as GBX2, is a human gene.^[1]

[edit] References

^ Entrez Gene: GBX2 gastrulation brain homeobox 2.

[edit] Further reading

Heimbucher T, Murko C, Bajoghli B, et al. (2007). "Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.". Mol. Cell. Biol. 27 (1): 340-51. doi:10.1128/MCB.00811-06. PMID 17060451.
Glinsky GV, Berezovska O, Glinskii AB (2005). "Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.". J. Clin. Invest. 115 (6): 1503-21. doi:10.1172/JCI23412. PMID 15931389.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Gao AC, Lou W, Isaacs JT (2000). "Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene.". Clin. Cancer Res. 6 (2): 493-7. PMID 10690529.
Gao AC, Lou W, Isaacs JT (1998). "Down-regulation of homeobox gene GBX2 expression inhibits human prostate cancer clonogenic ability and tumorigenicity.". Cancer Res. 58 (7): 1391-4. PMID 9537237.
Kowenz-Leutz E, Herr P, Niss K, Leutz A (1997). "The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.". Cell 91 (2): 185-95. PMID 9346236.
Lin X, Swaroop A, Vaccarino FM, et al. (1997). "Characterization and sequence analysis of the human homeobox-containing gene GBX2.". Genomics 31 (3): 335-42. doi:10.1006/geno.1996.0056. PMID 8838315.
Matsui T, Hirai M, Hirano M, Kurosawa Y (1994). "The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans.". FEBS Lett. 336 (1): 107-10. PMID 7903253.