GBP2

From Wikipedia, the free encyclopedia

Guanylate binding protein 2, interferon-inducible

Identifiers

External IDs

OMIM: 600412 MGI: 95666 HomoloGene: 86912

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• membrane
Biological Process:	• immune response

Orthologs

Human

Mouse

Entrez

2634

14468

Refseq

NM_004120 (mRNA)
NP_004111 (protein)

XM_001004411 (mRNA)
XP_001004411 (protein)

Pubmed search

[1]

[2]

Guanylate binding protein 2, interferon-inducible, also known as GBP2, is a human gene.^[1]

Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP.^[1]

[edit] References

^ ^a ^b Entrez Gene: GBP2 guanylate binding protein 2, interferon-inducible.

[edit] Further reading

Cheng YS, Patterson CE, Staeheli P (1991). "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.". Mol. Cell. Biol. 11 (9): 4717–25. PMID 1715024.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Neun R, Richter MF, Staeheli P, Schwemmle M (1996). "GTPase properties of the interferon-induced human guanylate-binding protein 2.". FEBS Lett. 390 (1): 69–72. PMID 8706832.
Nitsche EM, Moquin A, Adams PS, et al. (1996). "Differential display RT PCR of total RNA from human foreskin fibroblasts for investigation of androgen-dependent gene expression.". Am. J. Med. Genet. 63 (1): 231–8. doi:10.1002/(SICI)1096-8628(19960503)63:1<231::AID-AJMG40>3.0.CO;2-M. PMID 8723115.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Vestal DJ, Gorbacheva VY, Sen GC (2001). "Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions?". J. Interferon Cytokine Res. 20 (11): 991–1000. doi:10.1089/10799900050198435. PMID 11096456.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lukasiewicz R, Velazquez-Dones A, Huynh N, et al. (2007). "Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions.". J. Biol. Chem. 282 (32): 23036–43. doi:10.1074/jbc.M611305200. PMID 17517895.