GBP1

From Wikipedia, the free encyclopedia


Guanylate binding protein 1, interferon-inducible, 67kDa
PDB rendering based on 1dg3.
Available structures: 1dg3, 1f5n, 2b8w, 2b92, 2bc9, 2d4h
Identifiers
Symbol(s) GBP1;
External IDs OMIM: 600411 HomoloGene: 55626
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2633 n/a
Ensembl ENSG00000117228 n/a
Uniprot P32455 n/a
Refseq NM_002053 (mRNA)
NP_002044 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 1: 89.29 - 89.3 Mb n/a
Pubmed search [1] n/a

Guanylate binding protein 1, interferon-inducible, 67kDa, also known as GBP1, is a human gene.[1]

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3[1]

[edit] References

  1. ^ a b Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa.

[edit] Further reading

  • Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845-67. PMID 12488461. 
  • Naschberger E, Bauer M, Stürzl M (2006). "Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases.". Adv. Enzyme Regul. 45: 215-27. doi:10.1016/j.advenzreg.2005.02.011. PMID 16005050. 
  • Cheng YS, Patterson CE, Staeheli P (1991). "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.". Mol. Cell. Biol. 11 (9): 4717-25. PMID 1715024. 
  • Strehlow I, Lohmann-Matthes ML, Decker T (1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1.". Gene 144 (2): 295-9. PMID 7518790. 
  • Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1.". J. Leukoc. Biol. 60 (3): 423-31. PMID 8830800. 
  • Saunders NA, Smith RJ, Jetten AM (1999). "Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells.". J. Invest. Dermatol. 112 (6): 977-83. doi:10.1046/j.1523-1747.1999.00611.x. PMID 10383748. 
  • Prakash B, Praefcke GJ, Renault L, et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins.". Nature 403 (6769): 567-71. doi:10.1038/35000617. PMID 10676968. 
  • Kumar S, Li Q, Dua A, et al. (2001). "Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation.". J. Clin. Endocrinol. Metab. 86 (6): 2420-7. PMID 11397834. 
  • Guenzi E, Töpolt K, Cornali E, et al. (2001). "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.". EMBO J. 20 (20): 5568-77. doi:10.1093/emboj/20.20.5568. PMID 11598000. 
  • Lubeseder-Martellato C, Guenzi E, Jörg A, et al. (2002). "Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases.". Am. J. Pathol. 161 (5): 1749-59. PMID 12414522. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.". Mol. Cell Proteomics 1 (12): 947-55. PMID 12543931. 
  • Guenzi E, Töpolt K, Lubeseder-Martellato C, et al. (2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression.". EMBO J. 22 (15): 3772-82. doi:10.1093/emboj/cdg382. PMID 12881412. 
  • Naschberger E, Werner T, Vicente AB, et al. (2004). "Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells.". Biochem. J. 379 (Pt 2): 409-20. doi:10.1042/BJ20031873. PMID 14741045. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Praefcke GJ, Kloep S, Benscheid U, et al. (2004). "Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis.". J. Mol. Biol. 344 (1): 257-69. doi:10.1016/j.jmb.2004.09.026. PMID 15504415. 
  • Modiano N, Lu YE, Cresswell P (2005). "Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor.". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8680-5. doi:10.1073/pnas.0503227102. PMID 15937107. 
  • Ghosh A, Praefcke GJ, Renault L, et al. (2006). "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.". Nature 440 (7080): 101-4. doi:10.1038/nature04510. PMID 16511497. 
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