GBAS (gene)

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Glioblastoma amplified sequence
Identifiers
Symbol(s) GBAS; NIPSNAP2
External IDs OMIM: 603004 MGI: 1278343 HomoloGene: 1137
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2631 14467
Ensembl ENSG00000146729 ENSMUSG00000029432
Uniprot O75323 Q3TD78
Refseq NM_001483 (mRNA)
NP_001474 (protein)		 NM_008095 (mRNA)
NP_032121 (protein)
Location Chr 7: 56 - 56.04 Mb Chr 5: 130.04 - 130.07 Mb
Pubmed search [1] [2]

Glioblastoma amplified sequence, also known as GBAS, is a human gene.[1]

Chromosomal region 7p12, which contains GBAS, is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor.The predicted 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. The GBAS transcript is expressed most abundantly in heart and skeletal muscle. GBAS protein might be involved in vesicular transport.[1]

[edit] References

  1. ^ a b Entrez Gene: GBAS glioblastoma amplified sequence.

[edit] Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Seroussi E, Pan HQ, Kedra D, et al. (1998). "Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family.". Gene 212 (1): 13-20. PMID 9661659. 
  • Wang XY, Smith DI, Liu W, James CD (1998). "GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR.". Genomics 49 (3): 448-51. doi:10.1006/geno.1998.5239. PMID 9615231. 
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