GAS7

From Wikipedia, the free encyclopedia

Growth arrest-specific 7

Identifiers

GAS7; MLL/GAS7; KIAA0394; MGC1348

External IDs

OMIM: 603127 MGI: 1202388 HomoloGene: 69015

Gene ontology
Molecular Function:	• transcription factor activity • actin filament binding
Cellular Component:	• ruffle • actin filament
Biological Process:	• cell cycle arrest • multicellular organismal development • nervous system development • regulation of cell shape • actin filament polymerization • cell differentiation • actin filament bundle formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003644 (mRNA)
NP_003635 (protein)

NM_008088 (mRNA)
NP_032114 (protein)

Location

Chr 17: 9.75 - 10.04 Mb

Chr 11: 67.36 - 67.5 Mb

Pubmed search

[1]

[2]

Growth arrest-specific 7, also known as GAS7, is a human gene.^[1]

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: GAS7 growth arrest-specific 7.

[edit] Further reading

Kurtz A, Zimmer A (1995). "Interspecies fluorescence in situ hybridization further defines synteny homology between mouse chromosome 11 and human chromosome 17.". Mamm. Genome 6 (5): 379–80. PMID 7626897.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Ju YT, Chang AC, She BR, et al. (1998). "gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11423–8. PMID 9736752.
Megonigal MD, Cheung NK, Rappaport EF, et al. (2000). "Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2814–9. doi:10.1073/pnas.050397097. PMID 10706619.
She BR, Liou GG, Lin-Chao S (2002). "Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth.". Exp. Cell Res. 273 (1): 34–44. doi:10.1006/excr.2001.5435. PMID 11795944.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chao CC, Chang PY, Lu HH (2005). "Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth.". J. Neurosci. Res. 81 (2): 153–62. doi:10.1002/jnr.20552. PMID 15948147.