GAS2

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Growth arrest-specific 2
PDB rendering based on 1v5r.
Available structures: 1v5r
Identifiers
Symbol(s) GAS2; MGC32610
External IDs OMIM: 602835 MGI: 95657 HomoloGene: 31301
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2620 14453
Ensembl ENSG00000148935 ENSMUSG00000030498
Uniprot O43903 Q9D699
Refseq NM_005256 (mRNA)
NP_005247 (protein)		 NM_008087 (mRNA)
NP_032113 (protein)
Location Chr 11: 22.65 - 22.79 Mb Chr 7: 51.75 - 51.86 Mb
Pubmed search [1] [2]

Growth arrest-specific 2, also known as GAS2, is a human gene.[1]

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: GAS2 growth arrest-specific 2.

[edit] Further reading

  • Olson RE, Morello JA, Kieff ED (1975). "Antibiotic treatment of oral anaerobic infections.". Journal of oral surgery (American Dental Association : 1965) 33 (8): 619–21. PMID 1056466. 
  • Brancolini C, Bottega S, Schneider C (1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system.". J. Cell Biol. 117 (6): 1251–61. PMID 1607387. 
  • Schneider C, King RM, Philipson L (1988). "Genes specifically expressed at growth arrest of mammalian cells.". Cell 54 (6): 787–93. PMID 3409319. 
  • Collavin L, Buzzai M, Saccone S, et al. (1998). "cDNA characterization and chromosome mapping of the human GAS2 gene.". Genomics 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882. 
  • Sgorbissa A, Benetti R, Marzinotto S, et al. (2000). "Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis.". J. Cell. Sci. 112 ( Pt 23): 4475–82. PMID 10564664. 
  • Benetti R, Del Sal G, Monte M, et al. (2001). "The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.". EMBO J. 20 (11): 2702–14. doi:10.1093/emboj/20.11.2702. PMID 11387205. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMID 15124103. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Benetti R, Copetti T, Dell'Orso S, et al. (2005). "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.". J. Biol. Chem. 280 (23): 22070–80. doi:10.1074/jbc.M501810200. PMID 15817486. 
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