GAS1

From Wikipedia, the free encyclopedia

Growth arrest-specific 1

Identifiers

External IDs

OMIM: 139185 MGI: 95655 HomoloGene: 1548

Gene ontology
Molecular Function:	• molecular_function • receptor activity • protein binding • GPI anchor binding
Cellular Component:	• membrane • anchored to plasma membrane
Biological Process:	• cell cycle • cell cycle arrest • negative regulation of cell proliferation • programmed cell death • negative regulation of S phase of mitotic cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002048 (mRNA)
NP_002039 (protein)

NM_008086 (mRNA)
NP_032112 (protein)

Location

Chr 9: 88.75 - 88.75 Mb

Chr 13: 60.19 - 60.19 Mb

Pubmed search

[1]

[2]

Growth arrest-specific 1, also known as GAS1, is a human gene.^[1]

Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: GAS1 growth arrest-specific 1.

[edit] Further reading

Del Sal G, Ruaro ME, Philipson L, Schneider C (1992). "The growth arrest-specific gene, gas1, is involved in growth suppression.". Cell 70 (4): 595–607. PMID 1505026.
Wicking C, Breen M, Negus K, et al. (1994). "The human growth-arrest-specific gene GAS1 maps outside the candidate region of the gene for nevoid basal cell carcinoma syndrome.". Cytogenet. Cell Genet. 68 (1-2): 119–21. PMID 7956349.
Del Sal G, Collavin L, Ruaro ME, et al. (1994). "Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1848–52. PMID 8127893.
Evdokiou A, Webb GC, Peters GB, et al. (1994). "Localization of the human growth arrest-specific gene (GAS1) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies.". Genomics 18 (3): 731–3. PMID 8307588.
Evdokiou A, Cowled PA (1998). "Tumor-suppressive activity of the growth arrest-specific gene GAS1 in human tumor cell lines.". Int. J. Cancer 75 (4): 568–77. PMID 9466658.
Stebel M, Vatta P, Ruaro ME, et al. (2000). "The growth suppressing gas1 product is a GPI-linked protein.". FEBS Lett. 481 (2): 152–8. PMID 10996315.
Lee CS, Buttitta L, Fan CM (2001). "Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11347–52. doi:10.1073/pnas.201418298. PMID 11572986.
Baladrón V, Ruiz-Hidalgo MJ, Bonvini E, et al. (2002). "The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system.". Biochem. Biophys. Res. Commun. 291 (2): 193–204. doi:10.1006/bbrc.2002.6431. PMID 11846389.
Mellström B, Ceña V, Lamas M, et al. (2002). "Gas1 is induced during and participates in excitotoxic neuronal death.". Mol. Cell. Neurosci. 19 (3): 417–29. doi:10.1006/mcne.2001.1092. PMID 11906213.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Xu Y, Kulkosky J, Acheampong E, et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy.". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–5. doi:10.1073/pnas.0304859101. PMID 15103018.
Cabrera JR, Sanchez-Pulido L, Rojas AM, et al. (2006). "Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling.". J. Biol. Chem. 281 (20): 14330–9. doi:10.1074/jbc.M509572200. PMID 16551639.