GAPDHS

From Wikipedia, the free encyclopedia

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

Identifiers

GAPDHS; GAPD2; GAPDH-2; GAPDS; HSD-35

External IDs

OMIM: 609169 MGI: 95653 HomoloGene: 56402

Gene ontology
Molecular Function:	• glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity • oxidoreductase activity • NAD binding
Cellular Component:	• microtubule-based flagellum
Biological Process:	• glucose metabolic process • glycolysis • sperm motility • positive regulation of glycolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014364 (mRNA)
NP_055179 (protein)

NM_008085 (mRNA)
NP_032111 (protein)

Location

Chr 19: 40.72 - 40.73 Mb

Chr 7: 30.44 - 30.45 Mb

Pubmed search

[1]

[2]

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic, also known as GAPDHS, is a human gene.^[1]

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.^[1]

[edit] References

^ ^a ^b Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic.

[edit] Further reading

Cooper TG, Yeung CH (2001). "Approaches to post-testicular contraception.". Asian J. Androl. 1 (1-2): 29–36. PMID 11225901.
Benham FJ, Povey S (1989). "Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations.". Genomics 5 (2): 209–14. PMID 2793178.
Peterson RN, Freund M (1973). "Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa.". Biol. Reprod. 8 (3): 350–7. PMID 4349855.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Westhoff D, Kamp G (1997). "Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa.". J. Cell. Sci. 110 ( Pt 15): 1821–9. PMID 9264469.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S (2000). "L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa.". Mol. Hum. Reprod. 6 (2): 127–36. PMID 10655454.
Welch JE, Brown PL, O'Brien DA, et al. (2000). "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells.". J. Androl. 21 (2): 328–38. PMID 10714828.
Bone W, Jones AR, Morin C, et al. (2001). "Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro.". J. Androl. 22 (3): 464–70. PMID 11330647.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Li Y, Nowotny P, Holmans P, et al. (2004). "Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15688–93. doi:10.1073/pnas.0403535101. PMID 15507493.
Kodama R, Kondo T, Yokote H, et al. (2006). "Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+).". Genes Cells 10 (12): 1211–9. doi:10.1111/j.1365-2443.2005.00911.x. PMID 16324157.
Welch JE, Barbee RR, Magyar PL, et al. (2007). "Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis.". Mol. Reprod. Dev. 73 (8): 1052–60. doi:10.1002/mrd.20235. PMID 16700075.
Yatsenko AN, Roy A, Chen R, et al. (2007). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization.". Hum. Mol. Genet. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.