Ganglioside GM2 activator protein
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Ganglioside GM2 activator protein is (GM2-AP) is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation.
This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
It was identified as a member of ML domain family of proteins involved in innate immunity and lipid metabolism in SMART database. [1].
[edit] External links
- Uniprot entry
- UMich Orientation of Proteins in Membranes families/superfamily-114 - Calculated orientations of Ganglioside GM2 activator proteins in membrane
[edit] See also
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