GANAB

From Wikipedia, the free encyclopedia

Glucosidase, alpha; neutral AB

Identifiers

GANAB; G2AN; GluII; KIAA0088

External IDs

OMIM: 104160 MGI: 1097667 HomoloGene: 5426

Gene ontology
Molecular Function:	• hydrolase activity, hydrolyzing O-glycosyl compounds • protein binding • hydrolase activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• carbohydrate metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_198334 (mRNA)
NP_938148 (protein)

NM_008060 (mRNA)
NP_032086 (protein)

Location

Chr 11: 62.15 - 62.17 Mb

Chr 19: 8.97 - 8.98 Mb

Pubmed search

[1]

[2]

Glucosidase, alpha; neutral AB, also known as GANAB, is a human gene.^[1]

[edit] References

^ Entrez Gene: GANAB glucosidase, alpha; neutral AB.

[edit] Further reading

Feizi T, Larkin M (1992). "AIDS and glycosylation.". Glycobiology 1 (1): 17–23. PMID 2136376.
Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.". Biochimie 83 (8): 783–90. PMID 11530211.
Fenouillet E, Gluckman JC (1991). "Effect of a glucosidase inhibitor on the bioactivity and immunoreactivity of human immunodeficiency virus type 1 envelope glycoprotein.". J. Gen. Virol. 72 ( Pt 8): 1919–26. PMID 1678778.
Ratner L, vander Heyden N, Dedera D (1991). "Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity.". Virology 181 (1): 180–92. PMID 1704656.
Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.". Virology 187 (1): 377–82. PMID 1736542.
Murphy CI, Lennick M, Lehar SM, et al. (1991). "Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding.". Genet. Anal. Tech. Appl. 7 (6): 160–71. PMID 2076345.
Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.". AIDS Res. Hum. Retroviruses 6 (3): 371–80. PMID 2187500.
Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. PMID 2283726.
Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.". J. Biol. Chem. 265 (18): 10373–82. PMID 2355006.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.". J. Virol. 63 (6): 2452–6. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
Walker BD, Kowalski M, Goh WC, et al. (1987). "Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 8120–4. PMID 2825177.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.". AIDS Res. Hum. Retroviruses 3 (3): 265–82. PMID 2829950.
Gruters RA, Neefjes JJ, Tersmette M, et al. (1987). "Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.". Nature 330 (6143): 74–7. doi:10.1038/330074a0. PMID 2959866.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.". Biochem. Biophys. Res. Commun. 141 (1): 33–8. PMID 3099781.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. PMID 3264072.
Martiniuk F, Ellenbogen A, Hirschhorn R (1985). "Identity of neutral alpha-glucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies.". J. Biol. Chem. 260 (2): 1238–42. PMID 3881423.
Martiniuk F, Smith M, Ellenbogen A, et al. (1983). "Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11.". Cytogenet. Cell Genet. 35 (2): 110–6. PMID 6342981.