Gamma-glutamyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a gamma-glutamyltransferase (EC 2.3.2.2) is an enzyme that catalyzes the chemical reaction

(5-L-glutamyl)-peptide + an amino acid $\rightleftharpoons$ peptide + 5-L-glutamyl amino acid

Thus, the two substrates of this enzyme are (5-L-glutamyl)-peptide and amino acid, whereas its two products are peptide and 5-L-glutamyl amino acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase. Other names in common use include glutamyl transpeptidase, alpha-glutamyl transpeptidase, gamma-glutamyl peptidyltransferase, gamma-glutamyl transpeptidase, gamma-GPT, gamma-GT, gamma-GTP, L-gamma-glutamyl transpeptidase, L-gamma-glutamyltransferase, L-glutamyltransferase, GGT, and gamma-glutamyltranspeptidase. This enzyme participates in 5 metabolic pathways: taurine and hypotaurine metabolism, selenoamino acid metabolism, cyanoamino acid metabolism, glutathione metabolism, and arachidonic acid metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2DBU, 2DBW, 2DBX, 2DG5, 2E0W, 2E0X, 2E0Y, and 2NQO.

[edit] References

IUBMB entry for 2.3.2.2
BRENDA references for 2.3.2.2 (Recommended.)
PubMed references for 2.3.2.2
PubMed Central references for 2.3.2.2
Google Scholar references for 2.3.2.2
Goore MY, Thompson JF (1967). "Gamma-glutamyl transpeptidase from kidney bean fruit. I Purification and mechanism of action". Biochim. Biophys. Acta. 132: 15–26. PMID 6030345.
Leibach FH and Binkley F (1968). "gamma-Glutamyl transferase of swine kidney". Arch. Biochem. Biophys. 127: 292–301.