Gamma-glutamylhistamine synthase

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In enzymology, a gamma-glutamylhistamine synthase (EC 6.3.2.18) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + histamine products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine

The 3 substrates of this enzyme are ATP, L-glutamate, and histamine, whereas its two products are products of ATP breakdown and Nalpha-gamma-L-glutamylhistamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:histamine ligase. Other names in common use include gamma-glutaminylhistamine synthetase, and gamma-GHA synthetase.

[edit] References

• IUBMB entry for 6.3.2.18
• BRENDA references for 6.3.2.18 (Recommended.)
• PubMed references for 6.3.2.18
• PubMed Central references for 6.3.2.18
• Google Scholar references for 6.3.2.18
• Stein C, Weinreich D (1982). "An in vitro characterization of gamma-glutamylhistamine synthetase: a novel enzyme catalyzing histamine metabolism in the central nervous system of the marine mollusk, Aplysia californica". J. Neurochem. 38: 204–14. doi:10.1111/j.1471-4159.1982.tb10873.x. PMID 6125565. 

[edit] External links

The CAS registry number for this enzyme class is 82904-08-3.

• IUBMB entry for 6.3.2.18

• KEGG entry for 6.3.2.18

• BRENDA entry for 6.3.2.18

• NiceZyme view of 6.3.2.18

• EC2PDB: PDB structures for 6.3.2.18

• PRIAM entry for 6.3.2.18

• PUMA2 entry for 6.3.2.18

• IntEnz: Integrated Enzyme entry for 6.3.2.18

• MetaCyc entry for 6.3.2.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047914: gamma-glutamylhistamine synthase

• AMIGO entry for GO code 0047914: gamma-glutamylhistamine synthase