Galactosylxylosylprotein 3-beta-galactosyltransferase

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In enzymology, a galactosylxylosylprotein 3-beta-galactosyltransferase (EC 2.4.1.134) is an enzyme that catalyzes the chemical reaction

UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein \rightleftharpoons UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein

Thus, the two substrates of this enzyme are UDP-galactose and 4-beta-D-galactosyl-O-beta-D-xylosylprotein, whereas its two products are UDP and 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase. Other names in common use include galactosyltransferase II, and uridine diphosphogalactose-galactosylxylose galactosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.

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The CAS registry number for this enzyme class is 56626-21-2.

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