Galactose 1-dehydrogenase (NADP+)

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In enzymology, a galactose 1-dehydrogenase (NADP+) (EC 1.1.1.120) is an enzyme that catalyzes the chemical reaction

D-galactose + NADP⁺ $\rightleftharpoons$ D-galactonolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are D-galactose and NADP⁺, whereas its 3 products are D-galactonolactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-galactose:NADP+ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP+), and galactose 1-dehydrogenase (NADP+). This enzyme participates in galactose metabolism.

[edit] References

IUBMB entry for 1.1.1.120
BRENDA references for 1.1.1.120 (Recommended.)
PubMed references for 1.1.1.120
PubMed Central references for 1.1.1.120
Google Scholar references for 1.1.1.120
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Cline AL, Hu AS (1965). "Some physical properties of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240: 4498–502. PMID 5845849.
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