Galactose 1-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a galactose 1-dehydrogenase (EC 1.1.1.48) is an enzyme that catalyzes the chemical reaction

D-galactose + NAD⁺ D-galactono-1,4-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are D-galactose and NAD⁺, whereas its 3 products are D-galactono-1,4-lactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-galactose:NAD+ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase, beta-galactose dehydrogenase, and NAD+-dependent D-galactose dehydrogenase. This enzyme participates in galactose metabolism.

[edit] References

• IUBMB entry for 1.1.1.48
• BRENDA references for 1.1.1.48 (Recommended.)
• PubMed references for 1.1.1.48
• PubMed Central references for 1.1.1.48
• Google Scholar references for 1.1.1.48
• DE LEY J, DOUDOROFF M (1957). "The metabolism of D-galactose in Pseudomonas saccharophila". J. Biol. Chem. 227: 745–57. PMID 13462997. 
• Hu, ASL and Cline AL (1964). "The regulation of some sugar dehydrogenases in a pseudomonad". Biochim. Biophys. Acta 93: 237–245. 

[edit] External links

The CAS registry number for this enzyme class is 9028-54-0.

• IUBMB entry for 1.1.1.48

• KEGG entry for 1.1.1.48

• BRENDA entry for 1.1.1.48

• NiceZyme view of 1.1.1.48

• EC2PDB: PDB structures for 1.1.1.48

• PRIAM entry for 1.1.1.48

• PUMA2 entry for 1.1.1.48

• IntEnz: Integrated Enzyme entry for 1.1.1.48

• MetaCyc entry for 1.1.1.48

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019151: galactose 1-dehydrogenase

• AMIGO entry for GO code 0019151: galactose 1-dehydrogenase