Galactose-1-phosphate thymidylyltransferase

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In enzymology, a galactose-1-phosphate thymidylyltransferase (EC 2.7.7.32) is an enzyme that catalyzes the chemical reaction

dTTP + alpha-D-galactose 1-phosphate diphosphate + dTDP-galactose

Thus, the two substrates of this enzyme are dTTP and alpha-D-galactose 1-phosphate, whereas its two products are diphosphate and dTDP-galactose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase. Other names in common use include dTDP galactose pyrophosphorylase, galactose 1-phosphate thymidylyl transferase, thymidine diphosphogalactose pyrophosphorylase, thymidine triphosphate:alpha-D-galactose 1-phosphate, and thymidylyltransferase. This enzyme participates in nucleotide sugars metabolism.

[edit] References

• IUBMB entry for 2.7.7.32
• BRENDA references for 2.7.7.32 (Recommended.)
• PubMed references for 2.7.7.32
• PubMed Central references for 2.7.7.32
• Google Scholar references for 2.7.7.32
• Pazur JH and Anderson JS (1963). "Thymidine triphosphate: alpha-D-galactose 1-phosphate thymidylyltransferase from Streptococcus faecalis grown on D-galactose". J. Biol. Chem. 238: 3155–3160. 

[edit] External links

The CAS registry number for this enzyme class is 9023-25-0.

• IUBMB entry for 2.7.7.32

• KEGG entry for 2.7.7.32

• BRENDA entry for 2.7.7.32

• NiceZyme view of 2.7.7.32

• EC2PDB: PDB structures for 2.7.7.32

• PRIAM entry for 2.7.7.32

• PUMA2 entry for 2.7.7.32

• IntEnz: Integrated Enzyme entry for 2.7.7.32

• MetaCyc entry for 2.7.7.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047342: galactose-1-phosphate thymidylyltransferase

• AMIGO entry for GO code 0047342: galactose-1-phosphate thymidylyltransferase