GAL3ST1

From Wikipedia, the free encyclopedia

Galactose-3-O-sulfotransferase 1

Identifiers

External IDs

OMIM: 602300 MGI: 1858277 HomoloGene: 3574

Gene ontology
Molecular Function:	• galactosylceramide sulfotransferase activity • sulfotransferase activity • transferase activity
Cellular Component:	• membrane fraction • Golgi apparatus • integral to plasma membrane • membrane
Biological Process:	• protein amino acid N-linked glycosylation • galactosylceramide biosynthetic process • spermatogenesis • biosynthetic process • myelination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004861 (mRNA)
NP_004852 (protein)

NM_016922 (mRNA)
NP_058618 (protein)

Location

Chr 22: 29.28 - 29.29 Mb

Chr 11: 3.88 - 3.9 Mb

Pubmed search

[1]

[2]

Galactose-3-O-sulfotransferase 1, also known as GAL3ST1, is a human gene.^[1]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[1]

[edit] References

^ ^a ^b Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1.

[edit] Further reading

Siegrist HP, Jutzi H, Steck AJ, et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures.". Biochim. Biophys. Acta 489 (1): 58–63. PMID 911873.
Stein C, Gieselmann V, Kreysing J, et al. (1989). "Cloning and expression of human arylsulfatase A.". J. Biol. Chem. 264 (2): 1252–9. PMID 2562955.
Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney.". Biochem. Biophys. Res. Commun. 52 (3): 951–8. PMID 4710574.
Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain.". J. Biol. Chem. 246 (15): 4694–702. PMID 5562350.
Costantino-Ceccarini E, Waehneldt TV, Ginalski H, et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development.". Neurochem. Res. 7 (1): 1–12. PMID 6280086.
Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain.". J. Neurochem. 38 (1): 233–41. PMID 6955451.
Honke K, Yamane M, Ishii A, et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells.". J. Biochem. 119 (3): 421–7. PMID 8830034.
Honke K, Tsuda M, Hirahara Y, et al. (1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase.". J. Biol. Chem. 272 (8): 4864–8. PMID 9030544.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene.". Eur. J. Biochem. 267 (9): 2672–9. PMID 10785389.
Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase.". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMID 12175333.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.