Gadd45

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The Growth Arrest and DNA Damage gadd45 genes, including GADD45A (originally termed gadd45) GADD45B (originally termed MyD118), & GADD45G (originally termed CR6) are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation. Gadd45 proteins interact with other proteins implicated in stress responses, including PCNA, p21, Cdc2/CyclinB1, MEKK4 & p38 kinase.[1] [2]

Contents

[edit] History

Gadd45a was discovered & characterized in the laboratory of Dr. Albert Fornace Jr. in 1988. [3]

Gadd45b (MyD118) was discovered & characterized in the laboratories of Drs Dan A.Liebermann & Barbara Hoffman in 1991.[4]

Gadd45g (CR6) was discovered & characterized in the laboratories of Drs Keneneth Smith Dan A.Liebermann & Barbara Hoffman in 1993 & 1999.[5] [6]

[edit] See also

[edit] References

  1. ^ Fornace AJ, Jackman J, Hollander MC, Hoffman-Liebermann B, Liebermann DA (1992). "Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest". Ann. N. Y. Acad. Sci. 663: 139–53. PMID 1482047. 
  2. ^ Liebermann DA, Hoffman B (2002). "Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation". Leukemia 16 (4): 527–41. doi:10.1038/sj.leu.2402477. PMID 11960329. 
  3. ^ Fornace AJ, Alamo I, Hollander MC (1988). "DNA damage-inducible transcripts in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 8800–4. PMID 3194391. 
  4. ^ Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA (1991). "Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines". Oncogene 6 (1): 165–7. PMID 1899477. 
  5. ^ Zhang W, Bae I, Krishnaraju K, et al (1999). "CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control". Oncogene 18 (35): 4899–907. doi:10.1038/sj.onc.1202885. PMID 10490824. 
  6. ^ Beadling C, Johnson KW, Smith KA (1993). "Isolation of interleukin 2-induced immediate-early genes". Proc. Natl. Acad. Sci. U.S.A. 90 (7): 2719–23. PMID 7681987. 

[edit] External links

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