GADD45A

From Wikipedia, the free encyclopedia

Growth arrest and DNA-damage-inducible, alpha

Identifiers

GADD45A; DDIT1; GADD45

External IDs

OMIM: 126335 MGI: 107799 HomoloGene: 1449

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus
Biological Process:	• regulation of cyclin-dependent protein kinase activity • DNA repair • negative regulation of protein kinase activity • apoptosis • cell cycle • cell cycle arrest • centrosome cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001924 (mRNA)
NP_001915 (protein)

NM_007836 (mRNA)
NP_031862 (protein)

Location

Chr 1: 67.92 - 67.93 Mb

Chr 6: 66.96 - 66.97 Mb

Pubmed search

[1]

[2]

Growth arrest and DNA-damage-inducible, alpha, also known as GADD45A, is a human gene.^[1]

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.^[1]

[edit] See also

Gadd45

[edit] References

^ ^a ^b Entrez Gene: GADD45A growth arrest and DNA-damage-inducible, alpha.

[edit] Further reading

Hildesheim J, Fornace AJ (2003). "Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer.". Clin. Cancer Res. 8 (8): 2475-9. PMID 12171872.
Papathanasiou MA, Kerr NC, Robbins JH, et al. (1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.". Mol. Cell. Biol. 11 (2): 1009-16. PMID 1990262.
Chen IT, Smith ML, O'Connor PM, Fornace AJ (1995). "Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA.". Oncogene 11 (10): 1931-7. PMID 7478510.
Kearsey JM, Coates PJ, Prescott AR, et al. (1995). "Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.". Oncogene 11 (9): 1675-83. PMID 7478594.
Hall PA, Kearsey JM, Coates PJ, et al. (1995). "Characterisation of the interaction between PCNA and Gadd45.". Oncogene 10 (12): 2427-33. PMID 7784094.
Carrier F, Smith ML, Bae I, et al. (1995). "Characterization of human Gadd45, a p53-regulated protein.". J. Biol. Chem. 269 (51): 32672-7. PMID 7798274.
Smith ML, Chen IT, Zhan Q, et al. (1994). "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.". Science 266 (5189): 1376-80. PMID 7973727.
Hollander MC, Alamo I, Jackman J, et al. (1993). "Analysis of the mammalian gadd45 gene and its response to DNA damage.". J. Biol. Chem. 268 (32): 24385-93. PMID 8226988.
Warbrick E, Lane DP, Glover DM, Cox LS (1997). "Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair.". Oncogene 14 (19): 2313-21. doi:10.1038/sj.onc.1201072. PMID 9178907.
Warbrick E, Heatherington W, Lane DP, Glover DM (1998). "PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain.". Nucleic Acids Res. 26 (17): 3925-32. PMID 9705499.
Takekawa M, Saito H (1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.". Cell 95 (4): 521-30. PMID 9827804.
Carrier F, Georgel PT, Pourquier P, et al. (1999). "Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.". Mol. Cell. Biol. 19 (3): 1673-85. PMID 10022855.
Zhan Q, Antinore MJ, Wang XW, et al. (1999). "Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45.". Oncogene 18 (18): 2892-900. doi:10.1038/sj.onc.1202667. PMID 10362260.
Jin S, Antinore MJ, Lung FD, et al. (2000). "The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression.". J. Biol. Chem. 275 (22): 16602-8. doi:10.1074/jbc.M000284200. PMID 10747892.
Vairapandi M, Azam N, Balliet AG, et al. (2000). "Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control.". J. Biol. Chem. 275 (22): 16810-9. PMID 10828065.
Yi YW, Kim D, Jung N, et al. (2000). "Gadd45 family proteins are coactivators of nuclear hormone receptors.". Biochem. Biophys. Res. Commun. 272 (1): 193-8. PMID 10872826.
Zhao H, Jin S, Antinore MJ, et al. (2000). "The central region of Gadd45 is required for its interaction with p21/WAF1.". Exp. Cell Res. 258 (1): 92-100. doi:10.1006/excr.2000.4906. PMID 10912791.
Yang Q, Manicone A, Coursen JD, et al. (2001). "Identification of a functional domain in a GADD45-mediated G2/M checkpoint.". J. Biol. Chem. 275 (47): 36892-8. doi:10.1074/jbc.M005319200. PMID 10973963.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Kovalsky O, Lung FD, Roller PP, Fornace AJ (2001). "Oligomerization of human Gadd45a protein.". J. Biol. Chem. 276 (42): 39330-9. doi:10.1074/jbc.M105115200. PMID 11498536.